Focus from the first mug.
Most mushroom coffees say “lion's mane” as if that were a benefit, and never name a single active15. Rewire names and weighs every one, down to 5 mg of erinacine A1. The focus the studies found and the doses they used, every benefit one tap from its study. No other coffee comes close.
The leading lion's mane mycelium with 5 mg erinacine A, right in your coffee.
Riding along with the erinacine A is erinacine C, the most effective generator of nerve growth factor (NGF) discovered to date1. And a separate, highly potent lion's mane fruiting body extract with clinically significant doses of hericenones C, D, and E42. With nine actives in all, focus is just the start.
The ratio is our dose over the study's. The whole table, with every study, is on Evidence.
Every dose, next to its study →Seven a pack
Four mushroom coffees name no active. Rewire names five.
Erinacine A. Crosses into the brain and raises NGF, the signal that grows neurons and wires new connections between them. The one lion's mane compound with a human trial behind it1.
Erinacine C. Raises NGF and BDNF. In the lab it induced even more NGF than erinacine A1.
Hericenones C, D and E. The compounds behind lion's mane fruiting body's neurological activity, and entirely missing from every other product42. They raise NGF in the brain's astrocytes. The fruiting body also raises BDNF70.
Per serving, from each label15.
| Product | Mushroom a serving | Mushroom active named on the label | Also in the cup |
|---|---|---|---|
| Ryze | 2,000 mg, six-mushroom blend, no split | none | MCT and fibre, amounts not disclosed |
| MUD\WTR | 2,240 mg, four mushrooms on grain | none | cacao and spice, amounts not disclosed |
| Four Sigmatic Focus | 500 mg lion’s mane and chaga combined | none | — |
| Everyday Dose | 1,500 mg lion’s mane and chaga combined | none | 4,000 mg collagen, 150 mg L-theanine |
| Rewire Coffee | 2,000 mg lion’s mane: 1,000 mg of pure liquid-fermented mycelium powder, 1,000 mg concentrated fruiting body extract | erinacine A 5 mg1 and erinacine C 2.4 mg; hericenones C, D and E, 10 mg together42 | L-theanine 200 mg, creatine 5 g, NMN 1 g, MCT 4.2 g, rhodiola 170 mg, apigenin 50 mg, riboflavin 10 mg |
ErinaMax, Real Mycelium™, and Rewire: three products, the same ErinaPrime® mycelium.
All three deliver 5 mg of erinacine A a day from the same liquid-fermented lion's mane mycelium4, while Rewire also adds hericenones from its fruiting body extract and seven other focus actives. Two are capsules. One is a coffee.
| Nootropics Depot | Real Mushrooms | Rewire Coffee™ | |
|---|---|---|---|
| ErinaPrime® mycelium, 5 mg erinacine A a day | ErinaMax, two capsules · $12.83 a week | Real Mycelium™, two capsules · $11.66 a week | 1,000 mg1 |
| Erinacine C, assayed | not stated | not stated | 2.4 mg |
| Added fruiting body, 1,000 mg a day | Lion's Mane 8:1 Dual Extract, two capsules · no hericenones measured · $7.00 a week | Organic Lion's Mane Extract, two capsules · no hericenones measured · $4.08 a week | Already included: 1,000 mg, hericenones C, D, and E, 10 mg42 |
| A week | $19.83, mycelium and fruiting body only | $15.74, mycelium and fruiting body only | $14*, mycelium and fruiting body plus L-theanine, creatine, NMN, MCT, rhodiola, apigenin, and riboflavin, all at their studied doses |
The first mug. Then the first week. Then it keeps building.
Focus comes with the first mug. Caffeine with L-theanine: attention holds for hours while distraction falls30. Two fuels, sugar and MCT's ketones, so the energy holds through the afternoon40.
Creatine builds over the first week. The reserve your thinking draws from fills, and the afternoon slump loses its grip41.
By day fourteen NAD+ doubles at our dose of NMN2. Rhodiola carries you through the long stretch, steady where you would normally fade51.
Four weeks on, in L-theanine studies, words come faster and sleep comes easier21.
In lion's mane studies, recall improves by week eight39.
Seven things in the mug, and what each one does for you.
Each active named, at its studied dose, with where it acts. The whole map, twenty-eight pathways, is on Mechanisms.
Attention holds for hours while distraction falls30. L-theanine keeps it smooth — no jitters.
Erinacines and hericenones send NGF, which grows neurons and wires new connections between them1. In lion's mane studies, recall improves by week eight39.
NMN raises NAD+, the coenzyme every cell spends to make energy and repair itself2. Apigenin blocks CD38, the enzyme that breaks it down46. Riboflavin turns the spent form back into NAD+6.
Turns the spent form back into NAD+ at Complex I6, so what NMN builds keeps working.
The reserve your thinking draws from fills, and the afternoon slump loses its grip41.
Sugar for now, MCT's ketones for the long stretch40. The energy holds through the afternoon.
Rhodiola carries you through the long stretch, steady where you would normally fade51. Two weeks on, fatigue eased in physicians on night duty.
Rewire includes Signal, Build, and Fuel: the first three stages of the mitochondrial cycle.
Healthspan Coffee™ includes the entire cycle, all five stages: 23 actives, one mug.
Healthspan Coffee →
Coffee with a touch of maple and cinnamon.
One sachet, hot water, stir. 122 mg caffeine, a moderately strong cup. L-theanine keeps it smooth — no jitters.